Absorption and Efficacy Studies by In Vitro Models
In vitro models mimic the different biological barriers and target organs by which it is possible to evaluate absorption and efficacy of formulations. Absorption studies permit the performing of several screening tests to preliminarily evaluate products, ingredients or formulations before proceeding with the next steps evaluation. In vitro target organs permit to define mechanisms of actions and then efficacy of products, ingredients or formulations.
In vitro models are less expensive, faster, and offer better controls of experimental variables than human or animal studies, so they can be easily exploited as screening, ranking, or categorizing tools.
The 3Rs:
- Reduce time
- Reduce cost
- Reduces the % of clinical trial failure
What Kind of Studies?
- Bioaccessibility: Fraction of active substance released by the product during gastrointestinal digestion and available for absorption.
- Bioavailability: Fraction of active substance absorbed by the body and able to reach the blood circulation.
- Efficacy: Ability of an active substance to perform its function on a biological tissue.
- Safety: Formulations and/or active ingredients must not have adverse effects on biological tissues.
Our Capabilities
Mérieux NutriSciences can support all your projects with a wide range of in vitro models.
- In vitro oral model: oral and sublingual absorption
- In vitro digestive model: bioaccessibility
- In vitro intestinal absorption model: bioavailability
- In vitro model: skin model for absorption & efficacy studies
- In vitro model: gut model
- In vitro model: hepatic model
- In vitro model: brain model
- In vitro model: prostate model
- In vitro model: heart and blood vessel models
What Kind of Market?
- Pharmaceuticals
- Dietary supplements
- Novel foods
- Fortified foods
- Medical devices
- Cosmetics
Learn More on Absorption Studies
Absorption Studies with In Vitro Models
Screening Protocol Study
Complete Protocol Study
Learn More on Efficacy Studies
Efficacy Studies with In Vitro Models
Absorption Evaluation
Efficacy Evaluation
Our Scientific Writing on Absorption and Efficacy Studies by In Vitro Models
- In vitro behaviour of chitosan coated liposomes: “Analysis of operating conditions influencing the morphology and in vitro behaviour of chitosan coated liposomes” J Nanomed Nanotechnol 5: 211.
- In vitro toxicity assessment of oral nanocarriers – “In vitro toxicity assessment of oral nanocarriers”, Advanced Drug Delivery Reviews, Volume 106, Part B, 2016, Pages 381-401, ISSN 0169-409X.
- Iron bioaccessibility, bioavailability, and intestinal absorption mechanisms – “Comparative Evaluation of Intestinal Absorption and Functional Value of Iron Dietary Supplements and Drug with Different Delivery Systems”, Molecules, 25, 5989.
- In vitro models that compare different commercial dietary supplements containing stabilized OSA to ascertain their bioaccessibility, bioavailability, and safety in a model of human intestinal epithelium – “In vitro evaluation of different organic matrices used to modulate silicon bioavailability”, The FASEB Journal. 2020;34:12229–12238.
- Digestive model through an integrated in vitro approach – “Comparative evaluation of intestinal absorption and functional value of iron dietary supplements and drug with different delivery systems”, Molecules 2020, 25(24), 5989.
- In vitro efficacy testing to understand the mechanism of action – “Capryloyl glycine and soy isoflavonoids in hypertrichosis: an experimental and placebo-controlled clinical study”, DOI: 10.1111/jocd.14096 -J Cosmet Dermatol. 2021;20(Suppl. 1):18–22.
